Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres formatIsbn:Softcover 9783642790430 There is now considerable genetic van Oystaeyen There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late­ onset Alzheimer's disease The previous three ISCO conferences were subtitled "An In depth Analysis" In four sections Emphasis is placed on the use of cell and organ culture and lavage cell populations obtained from man and laboratory animals to elucidate cellular and molecular events occurring after their interaction with fibrous and non fibrous particulates including metal compounds